Publications
2021
Aronis KN, Prakosa A, Bergamaschi T, Berger RD, Boyle PM, Chrispin J, Ju S, Marine JE, Sinha S, Tandri H, Ashikaga H, Trayanova NA. Characterization of the Electrophysiologic Remodeling of Patients With Ischemic Cardiomyopathy by Clinical Measurements and Computer Simulations Coupled With Machine Learning. Front Physiol. 2021 Jul 14;12:684149. doi: 10.3389/fphys.2021.684149
Bear L, Cluitmans M, Abell E, Rogier J, Labrousse L, Cheng L, LeGrice I, Lever N, Sands G, Smaill B, Haïssaguerre M, Bernus O, Coronel R, Dubois R. Electrocardiographic Imaging of Repolarization Abnormalities. J Am Heart Assoc. 2021 May 4;10(9):e020153. doi: 10.1161/JAHA.120.020153
Boukens BJ, Potse M,
Coronel R.
Fibrosis and conduction abnormalities as basis for overlap of Brugada and early repolarization syndrome. Int J Mol Sci. 2021 Feb 4;22(4):1570.
doi: 10.3390/ijms22041570.
Boukens BJD, Dacey M, Meijborg VMF, Janse MJ, Hadaya J, Hanna P, Swid MA, Opthof T, Ardell J, Shivkumar K, Coronel R. Mechanism of ventricular premature beats elicited by left stellate ganglion stimulation during acute ischemia of the anterior left ventricle. Cardiovasc Res. 2021 Jul 27;117(9):2083-2091. doi: 10.1093/cvr/cvaa253.
Boyle PM, Ochs AR, Ali RL, Paliwal N, Trayanova NA. Characterizing the arrhythmogenic substrate in personalized models of atrial fibrillation: sensitivity to mesh resolution and pacing protocol in AF models. Europace. 2021 Mar 4;23(23 Suppl 1):i3-i11. doi: 10.1093/europace/euaa385.
Cadrin-Tourigny J, Bosman LP, …, Calkins H, Te Riele ASJM, James CA. Sudden Cardiac Death Prediction in Arrhythmogenic Right Ventricular Cardiomyopathy: A Multinational Collaboration. Circ Arrhythm Electrophysiol. 2021 Jan;14(1):e008509. doi: 10.1161/CIRCEP.120.008509.
Cadrin-Tourigny Julia, Hugh Calkins, et al. (more than 20 authors). Sudden cardiac death prediction in Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC): A multinational collaboration. Circulation: Arrhythmia and Electrophysiology. Volume 14, Issue 1, January 2021. doi: 10.1161/CIRCEP.120.008509
Choi YS, Yin RT, Pfenniger A,…, Arora RK, Efimov IR, Rogers JA. Fully implantable and bioresorbable cardiac pacemakers without leads or batteries. Nat Biotechnol. 2021 Oct;39(10):1228-1238. doi: 10.1038/s41587-021-00948-x.
Cluitmans MJM, Bear LR, , Nguyên UC, van Rees B, StoksJ, ter Bekke RMA, Mihl C, Heijman J, Lau KD, Vigmond E, Bayer J, Belterman CNW, Abell E, Labrousse L, Rogier J, Bernus O, Haïssaguerre M, Hassink RJ, Dubois R, Coronel R, Volders PGA. Noninvasive detection of spatiotemporal activation-repolarization 1 interactions that prime idiopathic ventricular fibrillation. 2021. Nature translational medicine (in press).
Coronel R, Potse M, Haissaguerre M, Derval N, Rivaud MR, Meijborg VM, Cluitmans M, Hocini M, Boukens BJ. Why ablation of sites with Purkinje activation is antiarrhythmic: ‘The interplay between fast activation and arrhythmogenesis’. Front Physiol. 2021 Mar 23;12:648396. doi: 10.3389/fphys.2021.648396.
Ernault A, Meijborg VM, Coronel R. Modulation of Cardiac Arrhythmogenesis by Epicardial Adipose Tissue: JACC State-of-the-Art Review. 2021. JACC (in press).
Fatkin D, Calkins H, Elliott P, James CA, Peters S, Kovacic JC. Contemporary and Future Approaches to Precision Medicine in Inherited Cardiomyopathies. J Am Coll Cardiol. 2021 May 25;77(20):2551-2572. doi: 10.1016/j.jacc.2020.12.072.
Gaur N, Q XY, Benoist D, Bernus O, Coronel R, Nattel S, Vigmond EJ. A Computational Model of Pig Ventricular Cardiomyocyte Electrophysiology and Calcium Handling: Translation from Pig to Human Electrophysiology. 2021. PLoS Comput Biol. 2021 Jun 30;17(6):e1009137. doi: 10.1371/journal.pcbi.1009137.
Gottlieb L, Vaillant F, Abell E, Belterman CN, Loyer V, El Hamrani D, Naulin J, Constantin M, Quesson B, Coronel R and Dekker LRC. Localized pulmonary vein scar promotes atrial fibrillation in increased left atrial pressure. Frontiers in Cardiac Electrophysiology. Front Physiol. 2021 Aug 25;12:709844. doi: 10.3389/fphys.2021.709844.
Gottlieb LA, Al Jefairi N, El Hamrani D, Naulin J, Lamy J, Kachenoura N, Constantin M, Quesson B, Cochet H, Coronel R, Dekker LRC. Reduction in left atrial and pulmonary vein dimensions after ablation therapy is mediated by scar. Int J Cardiol Heart Vasc. 2021 Oct 23;37:100894. doi: 10.1016/j.ijcha.2021.100894.
Gottlieb LA, Dekker LRC, Coronel R. The blinding period following ablation therapy for atrial fibrillation: pro- and antiarrhythmic pathophysiological mechanisms. JACC Clin Electrophysiol. 2021 Mar;7(3):416-430. doi: 10.1016/j.jacep.2021.01.011.
Gottlieb LA, El-Hamrani D, Naulin J, Sanchez Y Blanco L, Lamy J, Kachenoura N, Quesson B, Cochet H, Coronel R, Dekker LRC. A left lateral body position increases pulmonary vein stress in healthy humans. Physiological Reports (in press)
Gottlieb LA, Sanchez Y Blanco L, Hocini M, Dekker LRC, Coronel R. Self-reported onset of paroxysmal atrial fibrillation is related to sleeping body position. (Brief Research Report) Front Physiol. 2021 Jul 15;12:708650. doi: 10.3389/fphys.2021.708650.
Haïssaguerre M, Nademanee K, Sacher F, Cheniti G, Hocini M, Surget E, Dubois R, Vigmond E, Bernus O. Multisite conduction block in the epicardial substrate of Brugada syndrome. Heart Rhythm. 2021 Nov 1:S1547-5271(21)02322-5. doi: 10.1016/j.hrthm.2021.10.030
Haliot K, Dubes V, Constantin M, Pernot M, Labrousse L, Busuttil O, Walton RD, Bernus O, Rogier J, Nubret K, Dos Santos P, Benoist D, Haïssaguerre M, Magat J, Quesson B. A 3D high resolution MRI method for the visualization of cardiac fibro-fatty infiltrations. Sci Rep. 2021 Apr 29;11(1):9266. doi: 10.1038/s41598-021-85774-6
Krebs J, Mansi T, Delingette H, Lou B, Lima JAC, Tao S, Ciuffo LA, Norgard S, Butcher B, Lee WH, Chamera E, Dickfeld TM, Stillabower M, Marine JE, Weiss RG, Tomaselli GF, Halperin H, Wu KC, Ashikaga H. CinE caRdiac magneTic resonAnce to predIct veNTricular arrhYthmia (CERTAINTY). Sci Rep. (2021) 11. doi: 10.1038/s41598-021-02111-7
Moreno A, Walton RD, Bernus O, Vigmond EJ, Bayer JD. Low-energy, single-pulse surface stimulation defibrillates large mammalian ventricles. Heart Rhythm. 2021 Oct 12:S1547-5271(21)02222-0. doi: 10.1016/j.hrthm.2021.10.006.
Nademanee K, Veerakul G, Nogami A, Lou Q, Hocini M, Coronel R, Behr ER, Wilde A, Boukens BJ, Haissaguerre M. Mechanism of the effects of sodium channel blockade on the arrhythmogenic substrate of Brugada syndrome. Heart Rhythm. 2021 Nov 4:S1547-5271(21)02323-7. doi: 10.1016/j.hrthm.2021.10.031. Online ahead of print.
Prakosa A, Southworth MK, Avari Silva JN, Silva JR, Trayanova NA. Impact of augmented-reality improvement in ablation catheter navigation as assessed by virtual-heart simulations of ventricular tachycardia ablation. Comput Biol Med. 2021 Jun;133:104366. doi: 10.1016/j.compbiomed.2021.104366.
Rivaud MR, Bayer JD*, Cluitmans, van der Waal J, Bear LR, Boukens BJ, Belterman CN, Gottlieb L, Vaillant F, Abell E, Dubois R, Meijborg VMF, Coronel R. Critical repolarization gradients determine the induction of reentry-based Torsade de Pointes arrhythmia in models of long QT syndrome. Heart Rhythm. 2021 Feb;18(2):278-287. doi: 10.1016/j.hrthm.2020.09.020.
Sands GB, Ashton JL, Trew ML, Baddeley D, Walton RD, Benoist D, Efimov IR, Smith NP, Bernus O, Smaill BH. It's clearly the heart! Optical transparency, cardiac tissue imaging, and computer modelling. Prog Biophys Mol Biol. 2021 Jun 11:S0079-6107(21)00065-1. doi: 10.1016/j.pbiomolbio.2021.06.005.
Shade JK, Prakosa A, Popescu DM, Yu R, Okada DR, Chrispin J, Trayanova NA. Predicting risk of sudden cardiac death in patients with cardiac sarcoidosis using multimodality imaging and personalized heart modeling in a multivariable classifier. Sci Adv. 2021 Jul 28;7(31):eabi8020. doi: 10.1126/sciadv.abi8020.
Smoczynska A, Aarnink EW, Dunnink A, Bossu A, van Weperen VYH, Meijborg VMF, Beekman HDM, Coronel R, Vos M. Interplay between temporal and spatial dispersion of repolarization in the initiation and perpetuation of Torsade de Pointes in the chronic atrioventricular block dog. Am J Physiol Heart Circ Physiol. 2021 Sep 1;321(3):H569-H576. doi: 10.1152/ajpheart.00945.2020.
Van der Waal JG, Meijborg VMF, Belterman CNW, Streekstra GJ, Oostendorp TF, Coronel R. Ex vivo Validation of Noninvasive Epicardial and Endocardial Repolarization Mapping. Front Physiol. 2021 Oct 22;12:737609. doi: 10.3389/fphys.2021.737609
Wang W, Murray B, Tichnell C, Gilotra NA, Zimmerman SL, Gasperetti A, Scheel P, Tandri H, Calkins H, James CA. Clinical characteristics and risk stratification of desmoplakin cardiomyopathy. Europace. 2021 Aug 5:euab183. doi: 10.1093/europace/euab183.
Yang Q, Wei T, Yin RT, Wu M, Xu Y, Koo J, Choi YS, Xie Z,…, Efimov IR, Rogers JA. Photocurable bioresorbable adhesives as functional interfaces between flexible bioelectronic devices and soft biological tissues. Nat Mater. 2021 Nov;20(11):1559-1570. doi: 10.1038/s41563-021-01051-x.
Yu JK, Liang JA, Weinberg SH, Trayanova NA. Computational modeling of aberrant electrical activity following remuscularization with intramyocardially injected pluripotent stem cell-derived cardiomyocytes. J Mol Cell Cardiol. 2021 Sep 3;162:97-109. doi: 10.1016/j.yjmcc.2021.08.011.
Zhou S, AbdelWahab A, Sapp JL, Sung E, Aronis KN, Warren JW, MacInnis PJ, Shah R, Horá?ek BM, Berger R, Tandri H, Trayanova NA, Chrispin J. Prospective Multicenter Assessment of a New Intraprocedural Automated System for Localizing Idiopathic Ventricular Arrhythmia Origins. JACC Clin Electrophysiol. 2021 Mar;7(3):395-407. doi: 10.1016/j.jacep.2020.09.009.
Zhou S, Sung E, Prakosa A, Aronis KN, Chrispin J, Tandri H, AbdelWahab A, Horá?ek BM, Sapp JL, Trayanova NA. Feasibility study shows concordance between image-based virtual-heart ablation targets and predicted ECG-based arrhythmia exit-sites. Pacing Clin Electrophysiol. 2021 Mar;44(3):432-441. doi: 10.1111/pace.14181.
2020
Berenfeld O, Efimov I. Optical Mapping. Card Electrophysiol Clin. 2019 Sep; 11(3):495-510. https://doi.org/10.1016/j.ccep.2019.04.004
Boukens BJ, Benjacholamas V, van Amersfoort S, Meijborg VM, Schumacher CA, Jensen B, Haissaguerre M, Wilde A, Prechawat S, MD, Huntrakul A, Nademanee K*, Coronel R*. Structurally abnormal myocardium underlies ventricular fibrillation storms in a patient with the early repolarization pattern. JACC CE, Volume 6, Issue 11, 26 October 2020, Pages 1395-1404. doi: 10.1016/j.jacep.2020.06.027
Boukens BJ, Nademanee K, Coronel R. J-wave syndromes as part of the spectrum of structural heart diseases? JACC-CE 2020 (in press).
Boukens BJD, Dacey M, Meijborg VMF, Janse MJ, Hadaya J, Hanna P, Swid MA, Opthof T, Ardell J, Shivkumar K, Coronel R. ?Mechanism of ventricular premature beats elicited by left stellate ganglion stimulation during acute ischemia of the anterior left ventricle. Cardiovascular Research 2020 (in press).
Brennan JA, Chen Q, Gams A, Dyavanapalli J, Mendelowitz D, Peng W, Efimov IR. Evidence of Superior and Inferior Sinoatrial Nodes in the Mammalian Heart. J Am Coll Cardiol EP. 2020 Dec, 6 (14) 1827–1840. doi: 10.1101/2020.06.18.159939
Brun Francesca, Marta Gigli, Sharon L Graw, Daniel P Judge, Marco Merlo, Brittney Murray, Hugh Calkins, Gianfranco Sinagra, Matthew RG Taylor, Luisa Mestroni, Cynthia A James. FLNC truncations cause arrhythmogenic right ventricular cardiomyopathy. J Med Genet. 2020 Apr;57(4):254-257. doi: 10.1136/jmedgenet-2019-106394
Burnicka-Turek O, Broman MT, Steimle JD, Boukens BJ, Ikegami K, Nadadur RD, Qiao Y, Arnolds DE, Yang XH, Patel VV, Nobrega MA, Efimov IR, Moskowitz IP. Transcriptional patterning of the ventricular cardiac conduction system. Circ Res. 2020 Jul 3;127(2):e28-e43. doi: 10.1161/CIRCRESAHA.118.314460
Chen Z, Yin RT, Obaid SN, Tian J, Chen SW, Miniovich AN, Boyajian N, Efimov IR, Lu L. Flexible and Transparent Metal Oxide/Metal Grid Hybrid Interfaces for Electrophysiology and Optogenetics. Adv Mat Tech 2020. doi: 10.1002/admt.202000322
Dhamala Jwala, Pradeep Bajracharya, Hermenegild J. Arevalo, John L. Sapp, B. Milan Horácek, Katherine C. Wub,
Natalia A. Trayanova, Linwei Wanga.
Embedding high-dimensional Bayesian optimization via generativemodeling: Parameter personalization of cardiac electrophysiologicalmodels. Medical Image Analysis.
doi: 10.1016/j.media.2020.101670
Fenske S, Hennis K, Roetzer R, Brox V, Becirovic E, Scharr A, Gruner C, Ziegler T, Mehlfeld V, Brennan JA, Efimov IR, Pauza A, Moser M, Wotjak C, Kupatt C, Goenner R, Zhang R, Zhang H, Zong X, Biel M, Wahl-Schott C. cAMP-dependent regulation of HCN4 controls the tonic entrainment process in sinoatrial node pacemaker cells. Nature Commmun, 2020 Nov 3;11(1): 5555. doi: 10.1038/s41467-020-19304-9
Gaur N, Ortega F, PhD, Verkerk AO, Mengarelli I, Krogh-Madsen T, Christini DJ, Coronel R, Vigmond EJ, Validation of quantitative measure of repolarization reserve as a novel marker of drug induced proarrhythmia. JMCC Volume 145, P122-132, August 01, 2020. doi: 10.1016/j.yjmcc.2020.04.019
George SA, Brennan JA, Efimov IR. Preclinical Platform for Cardiac Electrophysiology Assessment by Dual Voltage and Calcium Optical Mapping of Human Organotypic Cardiac Slices. J Vis Exp. 2020 Jun 16; (160). doi: 10.3791/60781
George SA, Kiss A, Obaid SN, Venegas A, Talapatra T, Wei C, Efimova T, Efimov IR. p38δ genetic ablation protects female mice from anthracycline cardiotoxicity. Am J Physiol Heart Circ Physiol 319: H775–H786, 2020. doi: 10.1101/2020.03.02.973347
Handa BS, Li X, Aras KK, Qureshi NA, Mann I, Chowdhury RA, Kanagaratnam P, Efimov IR, Peters NS, Ng FS. Granger Causality-based analysis for classification of fibrillation mechanisms and localization of rotational drivers. Circ Arrhythm Electrophysiol. 2020 Mar;13(3): e008237. doi: 10.1161/CIRCEP.119.008237
Heravi Amir S., Lacey H. Etzkorn, Jacek K. Urbanek, Ciprian M. Crainiceanu, Naresh M. Punjabi, Hiroshi Ashikaga, Todd T. Brown, Matthew J. Budoff, Gypsyamber D’Souza, Jared W. Magnani, Frank J. Palella Jr, Ronald D. Berger, Katherine C. Wu, Wendy S. Post. HIV infection is associated with variability in ventricular repolarization: the Multicenter AIDS Cohort Study (MACS). Circulation. 2020 Jan 21;141(3):176-187. doi: 10.1161/CIRCULATIONAHA.119.043042
Knottnerus S, Mengarelli I, Wüst R, Baartscheer A, Bleeker J, Coronel R, Ferdinandusse S, Guan K, IJlst L, Li W, Luo X, Portero V, Ulbricht Y, Visser G, Wanders R, Wijburg F, Verkerk AO, Houtkooper R, Bezzina CR. Electrophysiological abnormalities in VLCAD deficient hiPSC-cardiomyocytes can be improved by lowering accumulation of fatty acid oxidation intermediates. Int J Mol Sciences 2020. Apr 8;21(7):2589. doi: 10.3390/ijms21072589.
Konstantinos N. Aronis, Rheeda L. Ali, Adityo Prakosa, Hiroshi Ashikaga, Ronald D. Berger, Joe B. Hakim, Jialiu Liang, Harikrishna Tandri, Fei Teng, Jonathan Chrispin,
Natalia A. Trayanova.
Accurate Conduction Velocity Maps and Their Association With Scar Distribution on Magnetic Resonance Imaging in Patients With Postinfarction Ventricular Tachycardias. Circulation: Arrhythmia and Electrophysiology.
doi: 10.1161/CIRCEP.119.007792
M. Han, L. Chen, K. Aras, C. Liang, X. Chen, H. Zhao, K. Li, N.R. Faye, B. Sun, J.-H. Kim, W. Bai, Q. Yang, Y. Ma, W. Lu, E. Song, J.M. Baek, Y. Lee, C. Liu, J.B. Model, G. Yang, R. Ghaffari, Y. Huang, I.R. Efimov and J.A. Rogers, “Catheter-integrated Soft Multilayer Electronic Arrays for Multiplexed Sensing and Actuation During Cardiac Surgery,” Nature Biomedical Engineering 4, 997-1009 (2020). doi: 10.1038/s41551-020-00604-w
Malik Nitin, Sithu Win, Cynthia A. James, Shelby Kutty, Monica Mukherjee, Nisha A. Gilotra, Crystal Tichnell, Brittney Murray, Julia Agafonova, Harikrishna Tandri, Hugh Calkins, and Allison G. Hays. Right Ventricular Strain Predicts Structural Disease Progression in Patients With Arrhythmogenic Right Ventricular Cardiomyopathy. J Am Heart Assoc 2020; 9: e015016. doi: 10.1161/JAHA.119.015016
Meijborg VMF*, Boukens BJD*, Janse MJ, Salavatian S, Dacey M , Yoshie K, Opthof T, Amer Swid M, Hoang JD, Hanna P, Ardell J, Shivkumar K, Coronel R. Stellate ganglion stimulation causes spatiotemporal changes of ventricular repolarization in pig. Heart Rhythm 2020. May;17(5 Pt A):795-803. doi: 10.1016/j.hrthm.2019.12.022
Mendonca Costa C, Anderson G, Meijborg V, O'Shea Ch, Shattock MJ, Kirchhof P, Coronel R, Niederer SA, Pavlovic D, Dhanjal T, Winter J. The amplitude-normalised area of a bipolar electrograms as a measure of local conduction delay in the heart. Front. Physiol., 19 May 2020. doi: 10.3389/fphys.2020.00465
Meo Marianna, Arnaud Denis, Frédéric Sacher, Josselin Duchâteau, Ghassen Cheniti, Stéphane Puyo, Laura Bear, Pierre Jaïs, Mélèze Hocini, Michel Haïssaguerre, Olivier Bernus, Rémi Dubois. Insights Into the Spatiotemporal Patterns of Complexity of Ventricular Fibrillation by Multilead Analysis of Body Surface Potential Maps. Front Physiol2020 Sep 23;11:554838. doi: 10.3389/fphys.2020.554838
Meo Marianna, Pietro Bonizzi, Laura R Bear, Matthijs Cluitmans, Emma Abell, Michel Haïssaguerre, Olivier Bernus, Rémi Dubois. Body Surface Mapping of Ventricular Repolarization Heterogeneity: An Ex-vivo Multiparameter Study. Front Physiol2020 Aug 13;11:933. doi: 10.3389/fphys.2020.00933
Murray Brittney, Crystal Tichnell, Harikrishna Tandri, Hugh Calkins, Peter van Tintelen, Daniel P. Judge, Cynthia A. James. Influence of Panel Selection on Yield of Clinically Useful Variants in rrhythmogenic Right Ventricular Cardiomyopathy Families. Circ Genom Precis Med. 2020 Oct;13(5):548-550. doi: 10.1161/CIRCGEN.120.003020
Nannes B, Quax R, Ashikaga H, Hocini M, Dubois R, Bernus O, Haïssaguerre M. Early signs of critical slowing down in heart surface electrograms of ventricular fibrillation victims. In: Krzhizhanovskaya V. et al. (eds) Computational Science – ICCS 2020. ICCS 2020. Lecture Notes in Computer Science, vol 12140. Springer, Cham. doi: 10.1007/978-3-030-50423-6_25
Obaid SN, Yin RT, Tian J, Chen Z, Chen SW, Lee KB, Boyajian N, Miniovich AN, Efimov IR, Lu L. Multifunctional Flexible Biointerfaces for Simultaneous Co-localized Optophysiology and Electrophysiology. Advanced Functional Materials. 2020, 30 (24): 1910027. doi: 10.1002/adfm.201910027
Okada DR, Miller J, Chrispin J, Prakosa A, Trayanova N, Jones S, Maggioni M, Wu KC. Substrate Spatial Complexity Analysis for the Prediction of Ventricular Arrhythmias in Patients with Ischemic Cardiomyopathy. Circ Arrhythm Electrophysiol. 2020 Apr;13(4):e007975. doi: 10.1161/CIRCEP.119.007975 (Editor’s Choice).
P Bosman Laurens, Julia Cadrin-Tourigny, Mimount Bourfiss, Mounes Aliyari Ghasabeh, Apurva Sharma, Crystal Tichnell, Rob W Roudijk, Brittney Murray, Harikrishna Tandri, Paul Khairy, Ihab R Kamel, Stefan L Zimmerman, Johannes B Reitsma, Folkert W Asselbergs, J Peter van Tintelen, Jeroen F van der Heijden, Richard N W Hauer, Hugh Calkins, Cynthia A James, Anneline S J M te Riele. Diagnosing arrhythmogenic right ventricular cardiomyopathy by 2010 Task Force Criteria: clinical performance and simplified practical implementation. EP Europace. doi: 10.1093/europace/euaa039
Rivaud MR*, Bayer JD*, Cluitmans, van der Waal J, Bear LR, Boukens BJ, Belterman CN, Gottlieb L, Vaillant F, Abell E, Dubois R, Meijborg VMF*, Coronel R*. Critical repolarization gradients determine the induction of reentry-based Torsade de Pointes arrhythmia in models of long QT syndrome. Heart Rhythm 2020 (in press).
Robinson FA, Mihealsick RP, Wagener BM, Hanna P, Poston MD, Efimov IR, Shivkumar K, Hoover DB. Role of angiotensin converting enzyme 2 and pericytes in cardiac complications of COVID-19 Infection. AJP: Heart & Circ. 2020 (in press).
Roney Caroline H., Rokas Bendikas, Farhad Pashakhanloo, Cesare Corrado, Edward J. Vigmond, Elliot R. McVeigh, Natalia A. Trayanova & Steven A. Niederer. Constructing a Human Atrial Fibre Atlas. Annals of Biomedical Engineering. doi: 10.1007/s10439-020-02525-w
Scheel Paul J., Roberta Florido, Steven Hsu, Brittney Murray, Crystal Tichnell, Cynthia A. James, Julia Agafonova, Harikrishna Tandri, Daniel P. Judge, Stuart D. Russell, Ryan J. Tedford, Hugh Calkins, and Nisha A. Gilotra. Safety and Utility of Cardiopulmonary Exercise Testing in Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia. Journal of the American Heart Association. doi: 10.1161/JAHA.119.013695
Shade JK, Cartoski MJ, Nikolov P, Prakosa A, Doshi A, Binka E, Olivieri L, Boyle PM, Spevak PJ, Trayanova N. Ventricular arrhythmia risk prediction in repaired Tetralogy of Fallot using personalized computational cardiac models. Heart Rhythm. 2020 Mar; 17(3):408-414. doi: 10.1016/j.hrthm.2019.10.002
Smirnov D, Pikunov A, Syunyaev R, Deviatiiarov R, Gusev O, Aras K, Gams A, Koppel A, Efimov IR, Genetic algorithm-based personalized models of human cardiac action potential. PLoS One. 2020 May 11;15(5):e0231695. doi: 10.1371/journal.pone.0231695
Trayanova Natalia A., Ashish N. Doshi, Adityo Prakosa. How personalized heart modeling can help treatment of lethal arrhythmias: A focus on ventricular tachycardia ablation strategies in post-infarction patients. Europe PMC. doi: 10.1002/wsbm.1477
Van Ouwerkerk AF, Bosada FM, van Duijvenboden K, Hill MC, Montefiori L, Scholman KT, Liu J, de Vries AAF, Boukens BJ, Ellinor PT, Goumans MJTH, Efimov IR, Nobrega MA, Barnett P, Martin JF, Christoffels VM. Identification of atrial fibrillation associated genes and functional non-coding variants. Nature Commun. 2019 Oct 18; 10(1):4755. doi: 10.1038/s41467-019-12721-5
Van der Waal J, Meijborg V, Schuler S, Coronel R*, Oostendorp T*. In silico validation of electrocardiographic imaging to reconstruct the endocardial and epicardial repolarization pattern using the equivalent dipole layer source model. Med Biol Eng Comput. 2020 Aug;58(8):1739-1749. PMID: 32474796. doi: 10.1007/s11517-020-02203-y
Weijia Wang, Crystal Tichnell, Brittney A. Murray, Julia Agafonova, Julia Cadrin-Tourigny, Stephen Chelko, Harikrishna Tandri, Hugh Calkins, Cynthia A. James. Exercise restriction is protective for genotype-positive family members of arrhythmogenic right ventricular cardiomyopathy patients. Europace. 2020 Aug 1;22(8):1270-1278. doi: 10.1093/europace/euaa105
Xie E, Mayer K, Capps MF, Barth A, Love CJ, Coronel R, Ashikaga H. Role of the Electrophysiological Substrate Associated With Spontaneous Initiation of Ventricular Fibrillation in Patients with Implantable Defibrillators. JCE 2020 (in press).
Xie Eric, Katarina Mayer, Melissa F. Capps, Andreas S. Barth, Charles J. Love, Ruben Coronel, Hiroshi Ashikaga. Mechanism of spontaneous initiation of ventricular fibrillation in patients with implantable defibrillators. J Cardiovasc Electrophysiol. July 2020. doi: 10.1111/jce.14648
Zhou S, Abdel-Wahab A, Sapp JL., Sung E., Aronis K., Warren JW, MacInnis P, Shah R, Horacek M, Berger R., Harikrisna T., Trayanova N, Chrispin J. Prospective multi-center assessment of a new intraprocedural automated system for localizing idiopathic ventricular arrhythmia origins. J Am Coll Cardiol EP. 2021 Mar, 7 (3) 395–407 (in press)
2019
Angel Moreno, Kendal Endicott, Matthew Skancke, Mary Kate Dwyer, Jaclyn Brennan, Igor R. Efimov, Gregory Trachiotis, David Mendelowitz and Matthew W. Kay, Sudden Heart Rate Reduction Upon Optogenetic Release of Acetylcholine From Cardiac Parasympathetic Neurons in Perfused Hearts, Front. Physiol., 28 January 2019. doi.org/10.3389/fphys.2019.00016
Antoinette F. van Ouwerkerk, Fernanda M. Bosada, Karel van Duijvenboden, Matthew C. Hill, Lindsey E. Montefiori, Koen T. Scholman, Jia Liu, Antoine A. F. de Vries, Bastiaan J. Boukens, Patrick T. Ellinor, Marie José T. H. Goumans, Igor R. Efimov, Marcelo A. Nobrega, Phil Barnett, James F. Martin & Vincent M. Christoffels. Identification of atrial fibrillation associated genes and functional non-coding variants. Nature Communications, volume 10, 4755 (2019). doi.org/10.1038/s41467-019-12721-5
Ashton JL, Sands GB, Khwaounjoo P, Ramlugun G, Trew ML, Walton R, Baddeley D, Bernus O, Efimov IR, Smaill BH. Cellular electrical coupling in the human heart: An image-based analysis pipeline. Heart Rhythm (Abstract 2019, in press).
Boukens BJ, Opthof T, Coronel R. J-Waves in Epicardial Electrograms Can Guide Ablation of Arrhythmogenic Substrates. Circ Res. 2019 Jan 18;124(2):205-207. doi: 10.1161/CIRCRESAHA.118.314414
Brianna Cathey, Sofian Obaid, Alexander M. Zolotarev, Roman A. Pryamonosov, Roman A. Syunyaev, Sharon A. George1 & Igor R. Efimov, Open-Source Multiparametric Optocardiography, Scientific reports, (2019) 9:721. DOI:10.1038/s41598-018-36809-y
Cartoski, M.J., Nikolov, P.P., Prakosa, A., Boyle P.M., Spevak P.J., Trayanova N.A. Computational Identification of Ventricular Arrhythmia Risk in Pediatric Myocarditis. Pediatr Cardiol (2019). https://doi.org/10.1007/s00246-019-02082-7
Dongdong Deng, Adityo Prakosa, Julie Shade, Plamen Nikolov and Natalia A. Trayanova, Sensitivity of ablation targets prediction to electrophysiological parameter variability in image-based computational models of ventricular tachycardia in post-patients. Frontiers in Physiology, 2019: 10 (628). DOI: 10.3389/fphys.2019.00628
Elise L. Kessler, Leonie van Stuijvenberg, Joanne J.A. van Bavel, Joëlle van Bennekom, Anne Zwartsen, Mathilde R. Rivaud, Aryan Vink, Igor R. Efimov, Alex V. Postma, J. Peter van Tintelen, Carol A. Remme, Marc A. Vos, Antje Banning, Teun P. de Boer, Ritva Tikkanen, Toon A.B. van Veen, Flotillins in the intercalated disc are potential modulators of cardiac excitability, Journal of Molecular and Cellular Cardiology 126 (2019) 86–95. doi.org/10.1016/j.yjmcc.2018.11.007
Gutruf P, Yin RT, Lee KB, Ausra J, Brennan JA, Qiao Y, Xie Z, Peralta R, Talarico O, Murillo A, Chen SW, Leshock JP, Haney CR, Waters EA, Zhang C, Luan H, Huang Y, Trachiotis G, Efimov IR, Rogers JA. Wireless battery-free fully implantable multimodal and multisite pacemakers for applications in small animal models, Nature Commun, 2019 Dec 17; 10(1):5742. doi: 10.1038/s41467-019-13637-w
Jason D. Roberts, ..., Hugh Calkins, Daniel P. Judge, Thomas J. Hund, Melvin M. Scheinman, Peter J. Mohler, ANK2 Dysfunction Predisposes to Arrhythmogenic Cardiomyopathy Independent of the Desmosome and is Reversible by Targeted Wnt/β-Catenin Activation. J Clin Invest. 2019;129(8):3171-3184. https://doi.org/10.1172/JCI125538
Julia Cadrin-Tourigny, Laurens P. Bosman, Anna Nozza, Weijia Wang, Rafik Tadros, Aditya Bhonsale, Mimount Bourfiss, Annik Fortier, Øyvind H. Lie, Ardan M. Saguner, Anneli Svensson, Antoine Andorin, Crystal Tichnell, Brittney Murray, Katja Zeppenfeld, Maarten P. van den Berg, Folkert W. Asselbergs, Arthur A.M. Wilde, Andrew D. Krahn, Mario Talajic, Lena Rivard, Stephen Chelko, Stefan L. Zimmerman, Ihab R. Kamel, Jane E. Crosson, Daniel P. Judge, Sing-Chien Yap, Jeroen F. Van der Heijden, Harikrishna Tandri, Jan D.H. Jongbloed, Marie-Claude Guertin, J. Peter van Tintelen, Pyotr G. Platonov, Firat Duru, Kristina H. Haugaa, Paul Khairy, Richard N.W. Hauer, Hugh Calkins, Anneline S.J.M. te Riele, Cynthia A. James. A New Prediction Model for Ventricular Arrhythmias in Arrhythmogenic Right Ventricular Cardiomyopathy. Eur Heart J, (2019) 0, 1-9. DOI 10.1093/eurheartj/ehz103.
Konstantinos N Aronis, Rheeda L Ali, Jialiu A Liang, Shijie Zhou1 and Natalia A Trayanova. Understanding AF Mechanisms Through Computational Modelling and Simulations. Arrhythmia & Electrophysiology Review 2019;8(3):210–9. DOI: https://doi.org/10.15420/aer.2019.28.2
Konstantinos N. Aronis, Rheeda Ali, Natalia A. Trayanova, The role of personalized atrial modeling in understanding atrialfibrillation mechanisms and improving treatment (2019). International Journal of Cardiology. doi.org/10.1016/j.ijcard.2019.01.096
Laura R. Bear, Oumayma Bouhamama, Matthijs Cluitmans, Josselin Duchateau, Richard D. Walton, Emma Abell, Charly Belterman, Michel Haissaguerre, Olivier Bernus, Ruben Coronel, Rémi Dubois. Advantages and pitfalls of non invasive electrocardiographic imaging. Journal of Electrocardiology, 2019. https://doi.org/10.1016/j.jelectrocard.2019.08.007
Laura R. Bear, Richard D. Walton, Emma Abell, Yves Coudière,
Michel Haissaguerre,
Olivier Bernus and
Rémi Dubois.
Optical Imaging of Ventricular Action Potentials in a Torso Tank: A New Platform for Non-Invasive Electrocardiographic Imaging Validation. Front. Physiol., 26 February 2019.
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Mélèze Hocini, Yuki Komatsu, Akihiko Nogami, Philippe Maury,Petr Peichl, Yu-ki Iwasaki, Keita Masuda, Arnaud Denis, Quentin Voglimacci-Stephanopoli, Dan Wichterle, Mitsuharu Kawamura, Seiji Fukamizu, Yasuhiro Yokoyama, Yasushi Mukai, Tomoo Harada, Kentaro Yoshida, Ryobun Yasuoka,Masayuki Igawa, Koji Ohira, Wataru Shimizu, Kazutaka Aonuma, Josef Kautzner, Michel Haïssaguerre, Masaki Ieda. Catheter Ablation of Refractory Ventricular Fibrillation Storm After Myocardial Infarction: A Multicenter Study. Circulation (April 2019). Doi 10.1161/CIRCULATIONAHA.118.037997
Michel Haïssaguerre, Koonlawee Nademanee, Méleze Hocini, MD, Ghassen Cheniti, MD, Josselin Duchateau, Antonio Frontera, Frédéric Sacher, Nicolas Derval, Arnaud Denis, Thomas Pambrun, Rémi Dubois, Pierre Jaïs, David Benoist, Richard D. Walton, Akihiko Nogami, Ruben Coronel, Mark Potse, Olivier Bernus. Depolarization versus repolarization abnormality underlying inferolateral J-wave syndromes: New concepts in sudden cardiac death with apparently normal hearts. Heart Rhythm 2019;16:781–790. https://doi.org/10.1016/j.hrthm.2018.10.040
Michel Haissaguerre, Ghassen Cheniti, William Escande, Alexandre Zhao, Méleze Hocini, Olivier Bernus. Idiopathic ventricular fibrillation with repetitive activity inducible within the distal Purkinje system. Heart Rhythm 2019;16:1268–1272. https://doi.org/10.1016/j.hrthm.2019.04.012
Namit Gaur, Thomas Hof, Michel Haissaguerre, Edward J. Vigmond, Propagation Failure by TRPM4 Overexpression, Biophysical Journal, Vol. 116, issue 3, p469-476, February 05, 2019. https://doi.org/10.1016/j.bpj.2018.11.3137
Patrick M. Boyle, William H. Franceschi, Marion Constantin, Claudia Hawks, Thomas Desplantez, Natalia A.Trayanova, Edward J.Vigmond, New insights on the cardiac safety factor: Unraveling the relationship between conduction velocity and robustness of propagation, Journal of Molecular and Cellular Cardiology, Volume 128, March 2019, Pages 117-128, https://doi.org/10.1016/j.yjmcc.2019.01.010.
Patrick M. Boyle, Tarek Zghaib, Sohail Zahid, Rheeda L. Ali, Dongdong Deng, William H. Franceschi, Joe B. Hakim, Michael J. Murphy, Adityo Prakosa, Stefan L. Zimmerman, Hiroshi Ashikaga, Joseph E. Marine, Aravindan Kolandaivelu, Saman Nazarian, David D. Spragg, Hugh Calkins and Natalia A. Trayanova. Computationally guided personalized targeted ablation of persistent atrial fibrillation. Nature biomedical engineering, 2019. https://doi.org/10.1038/s41551-019-0437-9
Philipp Gutruf, Rose T. Yin, K. Benjamin Lee, Jokubas Ausra, Jaclyn A. Brennan, Yun Qiao, Zhaoqian Xie, Roberto Peralta, Olivia Talarico, Alejandro Murillo, Sheena W. Chen, John P. Leshock, Chad R. Haney, Emily A. Waters, Changxing Zhang, Haiwen Luan, Yonggang Huang, Gregory Trachiotis, Igor R. Efimov & John A. Rogers. Wireless, battery-free, fully implantable multimodal and multisite pacemakers for applications in small animal models. Nature Communications, volume 10, 5742 (2019). doi.org/10.1038/s41467-019-13637-w
Rheeda L. Ali, Joe B. Hakim, Patrick M. Boyle, Sohail Zahid, Bhradeev Sivasambu, Joseph E. Marine, Hugh Calkins, Natalia A. Trayanova, and David D. Spragg. Arrhythmogenic propensity of the fibrotic substrate after atrial fibrillation ablation: a longitudinal study using magnetic resonance imaging-based atrial models. Cardiovascular Research (2019) 115, 1757–1765. https://doi.org/10.1093/cvr/cvz083
Susumu Tao, Joao AC Lima, Luisa A. Ciuffo, Konstantinos N. Aronis, Timm M. Dickfeld, Michael Stillabower, Robert G. Weiss, Gordon F. Tomaselli, Hiroshi Ashikaga, Katherine C. Wu. Impact of left atrial function on ventricular arrhythmia in primary prevention implantable cardioverter-defibrillator candidates. Submitted.
Uthman L, Nederlof R, Eerbeek O, Baartscheer A, Schumacher C, Buchholtz N, Hollmann MW, Coronel R, Weber NC, Zuurbier CJ, Delayed ischemic contracture onset by Empagliflozin associates with NHE-1 inhibition and is dependent on insulin in isolated mouse hearts. Cardiovasc Res. 2019 Jan 12. doi: 10.1093/cvr/cvz004.
Vigneshwaran V, Sands GB, LeGrice IJ, Smaill BH, Smith NP. Reconstruction of coronary circulation networks: A review of methods. Microcirculation. 2019 Jul;26(5):e12542. doi: 10.1111/micc.12542
2018
Aronis KN, Ashikaga H. Impact of number of co-existing rotors and inter-electrode distance on accuracy of rotor localization. J Electrocardiol. 2018; 51:82-91. doi:10.1016/j.jelectrocard.2017.08.032
Bayer Jason, Anton J Prassl, Ali Pashaei, Juan Gomez, Antonio Frontera, Aurel Neic, Gernot Plank, Edward J. Vigmond, “Universal Ventricular Coordinates: A Generic Framework for Describing Position within the Heart and Transferring Data,” Medical Image Analysis, 45 (2018), 83-93. https://doi.org/10.1016/j.media.2018.01.005
Bear Laura R., Ian J. LeGrice, Gregory B. Sands, Nigel A. Lever, Denis S. Loiselle, David J. Paterson, Leo K. Cheng, and Bruce H. Smaill. How Accurate is Inverse Electrocardiographic Mapping? A Systematic In vivo Evaluation. Circulation Arrhythmia and Electrophysiology. 2018; 11:e006108. doi: 10.1161/CIRCEP.117.006108.
Bear Laura R., Peter R Huntjens, Richard Walton, Olivier Bernus, Ruben Coronel, Rémi Dubois. Cardiac Electrical Dyssynchrony is Accurately Detected by Noninvasive Electrocardiographic Imaging. Heart Rhythm, Vol 15, No 7, July 2018. https://doi.org/10.1016/j.hrthm.2018.02.024
Bosman Laurens P., Arjan Sammani, Cynthia A. James, Julia Cadrin-Tourigny, Hugh Calkins, J. Peter van Tintelen, Richard N.W. Hauer, Folkert W. Asselbergs, Anneline S.J.M. teRiele. Predicting arrhythmic risk in arrhythmogenic right ventricular cardiomyopathy: A systematic review and meta-analysis. Heart Rhythm (2018), doi:10.1016/j.hrthm.2018.01.031.
Boyle PM, JB Hakim, S Zahid, WH Franceschi, MJ Murphy, EJ Vigmond, R Dubois, M Haïssaguerre, M Hocini, P Jaïs, NA Trayanova, H Cochet, Comparing Reentrant Drivers Predicted by Image-Based Computational Modeling and Mapped by Electrocardiographic Imaging in Persistent Atrial Fibrillation, Frontiers in Physiology, April 2018, Vol. 9, Article 414. doi: 10.3389/fphys.2018.00414.
Boyle Patrick M., Joe B. Hakim, Sohail Zahid, William H. Franceschi, Michael J. Murphy, Adityo Prakosa, Konstantinos N. Aronis, Tarek Zghaib, Muhammed Balouch, Esra G. Ipek, Jonathan Chrispin, Ronald D. Berger, Hiroshi Ashikaga, Joseph E. Marine, Hugh Calkins, Saman Nazarian, David D. Spragg and Natalia A. Trayanova, The Fibrotic Substrate in Persistent Atrial Fibrillation Patients: Comparison Between Predictions From Computational Modeling and Measurements From Focal Impulse and Rotor Mapping. Frontiers in Physiology, August 2018, Vol. 9, Article 1151. doi: 10.3389/fphys.2018.01151.
Coronel R. Activation-repolarization mapping to guide VT-ablation without the need to induce the arrhythmia. International Journal of Cardiology (2018) – 26607- 2. doi.org/10.1016/j.ijcard.2018.06.058.
Gloschat C, Aras K, Gupta S, Faye NR, Zhang H, Syunyaev RA, Pryamonosov RA, Rogers JM, Kay MW, Efimov IR, RHYTHM: An Open Source Imaging Toolkit for Cardiac Panoramic Optical Mapping. Scientific Reports, 2018 Feb 13; 8(1): 2921. PMID: 29440763. doi: 10.1038/s41598-018-21333-w
Haïssaguerre Michel, Koonlawee Nademanee, Mélèze Hocini, Ghassen Cheniti, Josselin Duchateau, Antonio Frontera, Frédéric Sacher, Nicolas Derval, Arnaud Denis, Thomas Pambrun, Rémi Dubois, Pierre Jaïs, David Benoist, Richard D. Walton, Akihiko Nogami, Ruben Coronel, Mark Potse, Olivier Bernus, Depolarization versus repolarization abnormality underlying inferolateral J wave syndromes – new concepts in sudden cardiac death with apparently normal hearts, Heart Rhythm 2018, doi.org/10.1016/j.hrthm.2018.10.040.
Haissaguerre Michel, Mélèze Hocini, Ghassen Cheniti, Josselin Duchateau, Frédéric Sacher, Stéphane Puyo, Hubert Cochet, Masateru Takigawa, Arnaud Denis, Ruairid Martin, Nicolas Derval, Pierre Bordachar, Philipper Ritter, Sylvain Ploux, Thomas Pambrun, Nicolas Klotz, Grégoire Massouillié, Xavier Pillois, Corentin Dallet, Jean-Jacques Schott, Solena Le Scouarnec, Michael J Ackerman, David Tester, Olivier Piot, Jean-Luc Pasquie, Christophe Leclerc, Jean-Sylvain Hermida, Estelle Gandjbakhch, Philippe Maury, Louis Labrousse, Ruben Coronel, Pierre Jais, David Benoist, Edward Vigmond, Mark Potse, Rick Walton, Koonlawee Nademanee, Olivier Bernus and Remi Dubois "Localized structural alterations underlying a subset of unexplained sudden cardiac death", Circ Arrhythm Electrophysiol. 2018; 11:e006120. doi: 10.1161/CIRCEP.117.006120.
Hsiao-Chun Amy Lin, Xosé Luís Déan-Ben, Michael Reiss, Verena Schöttle, Christian A. Wahl-Schott, Igor R. Efimov & Daniel Razansky, Ultrafast Volumetric Optoacoustic Imaging of Whole Isolated Beating Mouse Heart, Scientific reports (2018) 8:14132. doi:10.1038/s41598-018-32317-1
Jensen Bjarke, Bastiaan J Boukens, Dane A Crossley II, Justin Conner, Rajiv A Mohan, Karel van Duijvenboden, Alex V Postma, Christopher R Gloschat, Ruth M Elsey, David Sedmera, Igor R Efimov, Vincent M Christoffels, Specialized impulse conduction pathway in the alligator heart, eLife 2018;7:e32120. doi.org/10.7554/eLife.32120
Kedar K. Aras, Ndeye Rokhaya Faye, Brianna Cathey, Igor R. Efimov, Critical volume of human myocardium necessary to maintain ventricular fibrillation. Circ Arrhythm Electrophysiol. 2018;11:e006692. doi: 10.1161/CIRCEP.118.006692.
Khwaounjoo P, Trew ML, Sands GB, Legrice IJ, Gillis AM, Smaill BH. Cardiac fibrosis and ventricular arrhythmogenesis in hypertensive heart disease progression. Heart Rhythm 2018 (Abstract), Vol. 15, n°5, May supplement 2018. B-PO01-007
Loucks Alexandra D., Thomas O’Hara and Natalia A. Trayanova, Degradation of T-Tubular Microdomains and Altered cAMP Compartmentation Lead to Emergence of Arrhythmogenic Triggers in Heart Failure Myocytes: An in silico Study. Frontiers in Physiology, 2018, 9:1737. doi: 10.3389/fphys.2018.01737
M. Orgeron Gabriela, Anneline te Riele, Crystal Tichnell, Weijia Wang, Brittney Murray, Aditya Bhonsale, Daniel P. Judge, Ihab R. Kamel, Stephan L. Zimmerman, Harikrishna Tandri, Hugh Calkins and Cynthia A. James. Performance of the 2015 International Task Force Consensus Statement Risk Stratification Algorithm for Implantable Cardioverter-Defibrillator Placement in Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy. Circulation: Arrhythmia and Electrophysiology. 2018; 11:e005593. doi.org/10.1161/CIRCEP.117.005593.
Martinez Marine E., Richard D. Walton, Jason D. Bayer, Michel Haïssaguerre, Edward J. Vigmond, Mélèze Hocini and Olivier Bernus, "Role of the Purkinje-muscle junction on the ventricular repolarization heterogeneity in the healthy and ischemic ovine ventricular myocardium", Frontiers in Physiology, June 2018, Vol. 9, Article 718. doi: 10.3389/fphys.2018.00718
Orgeron Gabriela M., Aditya Bhonsale, Federico Migliore, Cynthia A. James, Crystal Tichnell, Brittney Murray, Emanuele Bertaglia, Julia Cadrin-Tourigny, Pietro De Franceschi, Jane Crosson, Harikrishna Tandri, Domenico Corrado, Hugh Calkins, Subcutaneous Implantable Cardioverter-Defibrillator in Patients With Arrhythmogenic Right Ventricular Cardiomyopathy / Dysplasia: A Transatlantic Experience, J Am Heart Assoc. 2018;7:e008782. doi: 10.1161/JAHA.118.008782.
Pashakhanloo F., Herzka D.A., Halperin H., McVeigh E.R.,
Trayanova N.A.,
Role of 3-Dimensional Architecture ofScar and Surviving Tissue in VentricularTachycardia, Circ Arrhythm Electrophysiol. 2018;11:e006131.
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Prakosa Adityo, Hermenegild J. Arevalo, Dongdong Deng, Patrick M. Boyle, Plamen P. Nikolov, Hiroshi Ashikaga, Joshua J. E. Blauer, Elyar Ghafoori, Carolyn J. Park, Robert C. Blake III, Frederick T. Han, Rob S. MacLeod, Henry R. Halperin, David J. Callans, Ravi Ranjan, Jonathan Chrispin, Saman Nazarian and Natalia A. Trayanova. Personalized virtual-heart technology for guiding the ablation of infarct-related ventricular tachycardia, Nature Biomedical Engineering, 2018, volume 2, 732–740. doi: 10.1038/s41551-018-0282-2
Qiao Y, Dong Q, Li B, Obaid S, Miccile C, Yin R, Talapatra T, Lin Z, Li S, Li Z, Efimov IR, Multiparametric slice culture platform for the investigation of human cardiac tissue physiology. Prog Biophys Mol Biol. 2018 Jun 27. pii: S0079-6107(18)30012-9. doi: 10.1016/j.pbiomolbio.2018.06.001.
Tsutsui Kenta, Oliver J. Monfredi, Syevda G. Sirenko-Tagirova, Larissa A. Maltseva, Rostislav Bychkov, Mary S. Kim, Bruce D. Ziman, Kirill V. Tarasov, Yelena S. Tarasova, Jing Zhang, Mingyi Wang, Alexander V. Maltsev, Jaclyn A. Brennan, Igor R. Efimov, Michael D. Stern, Victor A. Maltsev, Edward G. Lakatta, A coupled-clock system drives the automaticity of human sinoatrial nodal pacemaker cells, Sci. Signal. 11, eaap7608 (2018). doi: 10.1126/scisignal.aap7608.
Uthman L, Baartscheer A, Schumacher CA, Fiolet JWT, Kuschma MC, Hollmann MW, Coronel R, Weber NC, Zuurbier CJ. Direct Cardiac Actions of Sodium Glucose Cotransporter 2 Inhibitors Target Pathogenic Mechanisms Underlying Heart Failure in Diabetic Patients. Front Physiol. 2018 Nov 21;9:1575. doi: 10.3389/fphys.2018.01575
Veldkamp MW, Geuzebroek GSC, Baartscheer A, Verkerk AO, Schumacher CA, Suarez GG, Berger WR, Casini S, van Amersfoorth SCM, Scholman KT, Driessen AHG, Belterman CNW, van Ginneken ACG, de Groot JR, de Bakker JMT, Remme CA, Boukens BJ, Coronel R. Neurokinin-3 receptor activation selectively prolongs atrial refractoriness by inhibition of a background K+ channel. Nat Commun. 2018 Oct 19;9(1):4357. doi: 10.1038/s41467-018-06530-5.
Wang Weijia, Gabriela Orgeron, Crystal Tichnell, Brittney Murray, Jane Crosson, Oliver Monfredi, Julia Cadrin-Tourigny, Harikrishna Tandri, Hugh Calkins, Cynthia A. James, ScM, Impact of Exercise Restriction on Arrhythmic Risk Among Patients With Arrhythmogenic Right Ventricular Cardiomyopathy. J Am Heart Assoc. 2018;7:e008843. doi: 10.1161/JAHA.118.008843.
Wang Weijia, Julia Cadrin-Tourigny, Aditya Bhonsale, Crystal Tichnell, Brittney Murray, Oliver Monfredi, Jonathan Chrispin, Jane Crosson, Harikrishna Tandri, Cynthia A. James, Hugh Calkins, Arrhythmic outcome of arrhythmogenic right ventricular cardiomyopathy patients without implantable defibrillators. J Cardiovasc Electrophysiol. 2018;1–7. doi: 10.1111/jce.13668.
Zile Melanie A., and Natalia A. Trayanova, Increased thin filament activation enhances alternans in human chronic atrialfibrillation. Am J Physiol Heart Circ Physiol 315: H1453–H1462, 2018. doi:10.1152/ajpheart.00658.2017.
2017
Aronis KN, BergerRD, and Ashikaga H. Rotors: How do we know when they are real? Circ Arrhythm Electrophysiol. 2017; 10:e005634. doi:10.1161/CIRCEP.117.005634
Coronel R.
Restitution slope is determined by the steady state action potential duration: law and disorder. Cardiovasc Res. 2017 Jun 1; 113(7):705-707.
doi: 10.1093/cvr/cvx080.
Coronel R. The pro- or antiarrhythmic actions of polyunsaturated fatty acids and of cholesterol. Pharmacol Ther. 2017 Aug; 176:40-47. doi: 10.1016/j.pharmthera.2017.02.004. Epub 2017 Feb 3.
Kang C; Badiceanu A, Brennan JA, Gloschat C, Qiao Y, Trayanova N, Efimov IR, β-Adrenergic stimulation augments transmural dispersion of repolarization via modulation of delayed rectifier currents IKs and IKr in the human ventricle. Scientific Reports, 2017 Nov 21; 7(1): 15922. PMID: 29162896. DOI:10.1038/s41598-017-16218-3
Meijborg VMF, Belterman CNW, de Bakker JMT, Coronel R, Conrath CE. Mechano-electric coupling, heterogeneity in repolarization and the electrocardiographic T-wave. Prog Biophys Mol Biol. 2017 Nov; 130(Pt B):356-364. doi: 10.1016/j.pbiomolbio.2017.05.003. Epub 2017 May 17.
Sanjay R Kharche, Edward Vigmond, Igor Efimov, Halina Dobrzynski, "Computational assessment of the functional role of sinoatrial node exit pathways in the human heart," PloS ONE, 2(9): e0183727, 2017. doi 10.1371/journal.pone.0183727
Sanjay R Kharche, Edward Vigmond, Igor Efimov, Halina Dobrzynski, "Computational assessment of the functional role of sinoatrial node exit pathways in the human heart," PloS ONE, 2(9): e0183727, 2017. https://doi.org/10.1371/journal.pone.0183727
Smit NW, Cócera Ortega L, Végh AMD, Meijborg VMF, Smits AM, Klerk M, Tijsen AJM, Tan HL, Goumans MHT, Boink GJJ, Coronel R. Human Cardiomyocyte Progenitor Cells in Co-culture with Rat Cardiomyocytes Form a Pro-arrhythmic Substrate: Evidence for Two Different Arrhythmogenic Mechanisms. Front Physiol. 2017 Oct 12; 8:797. doi: 10.3389/fphys.2017.00797. eCollection 2017.
Veerman CC, Podliesna S, Tadros R, Lodder EM, Mengarelli I, de Jonge B, Beekman L, Barc J1, Wilders R, Wilde AAM, Boukens BJ, Coronel R, Verkerk AO, Remme CA, Bezzina CR. The Brugada Syndrome Susceptibility Gene HEY2 Modulates Cardiac Transmural Ion Channel Patterning and Electrical Heterogeneity. Circ Res. 2017 Aug 18; 121(5):537-548. doi: 10.1161 / CIRCRESAHA.117.310959. Epub 2017 Jun 21.
Vigmond EJ, Efimov IR, Rentschler SL, Coronel R, Boukens BJ. Fractionated electrograms with ST-segment elevation recorded from the human right ventricular outflow tract. Heart Rhythm Case Rep. 2017 Sep 28; 3(11):546-550. PMID: 29204352. doi: 10.1016/j.hrcr.2017.08.010
