Publications


2019

01. Konstantinos N. Aronis, Rheeda Ali, Natalia A. Trayanova, The role of personalized atrial modeling in understanding atrialfibrillation mechanisms and improving treatment (2019). International Journal of Cardiology. doi.org/10.1016/j.ijcard.2019.01.096
02. Ashton JL, Sands GB, Khwaounjoo P, Ramlugun G, Trew ML, Walton R, Baddeley D, Bernus O, Efimov IR, Smaill BH. Cellular electrical coupling in the human heart: An image-based analysis pipeline. Heart Rhythm (Abstract 2019, in press).
03. Laura R. Bear, Richard D. Walton, Emma Abell, Yves Coudière, Michel HaissaguerreOlivier Bernus and Rémi Dubois. Optical Imaging of Ventricular Action Potentials in a Torso Tank: A New Platform for Non-Invasive Electrocardiographic Imaging Validation. Front. Physiol., 26 February 2019. doi.org/10.3389/fphys.2019.00146
04. Boukens BJ, Opthof T, Coronel R. J-Waves in Epicardial Electrograms Can Guide Ablation of Arrhythmogenic Substrates. Circ Res. 2019 Jan 18;124(2):205-207. doi: 10.1161/CIRCRESAHA.118.314414
05. Patrick M. Boyle,  William H. Franceschi, Marion Constantin, Claudia Hawks, Thomas Desplantez, Natalia A.Trayanova, Edward J.Vigmond, New insights on the cardiac safety factor: Unraveling the relationship between conduction velocity and robustness of propagation, Journal of Molecular and Cellular Cardiology, Volume 128, March 2019, Pages 117-128, https://doi.org/10.1016/j.yjmcc.2019.01.010.
06.  Julia Cadrin-Tourigny, Laurens P. Bosman, Anna Nozza, Weijia Wang, Rafik Tadros, Aditya Bhonsale, Mimount Bourfiss, Annik Fortier, Øyvind H. Lie, Ardan M. Saguner, Anneli Svensson, Antoine Andorin, Crystal Tichnell, Brittney Murray, Katja Zeppenfeld, Maarten P. van den Berg, Folkert W. Asselbergs, Arthur A.M. Wilde, Andrew D. Krahn, Mario Talajic, Lena Rivard, Stephen Chelko, Stefan L. Zimmerman, Ihab R. Kamel, Jane E. Crosson, Daniel P. Judge, Sing-Chien Yap, Jeroen F. Van der Heijden, Harikrishna Tandri, Jan D.H. Jongbloed, Marie-Claude Guertin, J. Peter van Tintelen, Pyotr G. Platonov, Firat Duru, Kristina H. Haugaa, Paul Khairy, Richard N.W. Hauer, Hugh Calkins, Anneline S.J.M. te Riele, Cynthia A. James. A New Prediction Model for Ventricular Arrhythmias in Arrhythmogenic Right Ventricular Cardiomyopathy. Eur Heart J, (2019) 0, 1-9. DOI 10.1093/eurheartj/ehz103.
07. Cartoski, M.J., Nikolov, P.P., Prakosa, A., Boyle P.M., Spevak P.J., Trayanova N.A. Computational Identification of Ventricular Arrhythmia Risk in Pediatric Myocarditis. Pediatr Cardiol (2019). https://doi.org/10.1007/s00246-019-02082-7
08. Brianna Cathey, Sofian Obaid, Alexander M. Zolotarev, Roman A. Pryamonosov, Roman A. Syunyaev, Sharon A. George1 & Igor R. Efimov, Open-Source Multiparametric Optocardiography, Scientific reports, (2019) 9:721. DOI:10.1038/s41598-018-36809-y
09. Namit Gaur, Thomas Hof, Michel Haissaguerre, Edward J. Vigmond, Propagation Failure by TRPM4 Overexpression, Biophysical Journal, Vol. 116, issue 3, p469-476, February 05, 2019. https://doi.org/10.1016/j.bpj.2018.11.3137
10. Cynthia A. James and Hugh Calkins, Arrhythmogenic Right Ventricular Cardiomyopathy: Progress Toward Personalized Management. Annu. Rev. Med. 2019. 70:17.1–17.18. doi.org/10.1146/annurev-med-041217-010932
11. Elise L. Kessler, Leonie van Stuijvenberg, Joanne J.A. van Bavel, Joëlle van Bennekom, Anne Zwartsen, Mathilde R. Rivaud, Aryan Vink, Igor R. Efimov, Alex V. Postma, J. Peter van Tintelen, Carol A. Remme, Marc A. Vos, Antje Banning, Teun P. de Boer, Ritva Tikkanen, Toon A.B. van Veen, Flotillins in the intercalated disc are potential modulators of cardiac excitability,  Journal of Molecular and Cellular Cardiology 126 (2019) 86–95. doi.org/10.1016/j.yjmcc.2018.11.007
12. Mélèze Hocini, Yuki Komatsu, Akihiko Nogami, Philippe Maury,Petr Peichl, Yu-ki Iwasaki, Keita Masuda, Arnaud Denis, Quentin Voglimacci-Stephanopoli, Dan Wichterle, Mitsuharu Kawamura, Seiji Fukamizu, Yasuhiro Yokoyama, Yasushi Mukai, Tomoo Harada, Kentaro Yoshida, Ryobun Yasuoka,Masayuki Igawa, Koji Ohira, Wataru Shimizu, Kazutaka Aonuma, Josef Kautzner, Michel Haïssaguerre, Masaki Ieda. Catheter Ablation of Refractory Ventricular Fibrillation Storm After Myocardial Infarction: A Multicenter Study. Circulation (April 2019). Doi 10.1161/CIRCULATIONAHA.118.037997
13. Angel Moreno, Kendal Endicott, Matthew Skancke, Mary Kate Dwyer, Jaclyn Brennan, Igor R. Efimov, Gregory Trachiotis, David Mendelowitz and Matthew W. Kay, Sudden Heart Rate Reduction Upon Optogenetic Release of Acetylcholine From Cardiac Parasympathetic Neurons in Perfused Hearts, Front. Physiol., 28 January 2019. doi.org/10.3389/fphys.2019.00016
14. Jason D. Roberts, ..., Hugh Calkins, Daniel P. Judge, Thomas J. Hund, Melvin M. Scheinman, Peter J. Mohler, ANK2 Dysfunction Predisposes to Arrhythmogenic Cardiomyopathy Independent of the Desmosome and is Reversible by Targeted Wnt/β-Catenin Activation. J Clin Invest. 2019;129(8):3171-3184. https://doi.org/10.1172/JCI125538
15. Daniel Sohn, Konstantinos Aronis, Hiroshi Ashikaga, Scale-invariant structures of spiral waves. Computers in Biology and Medicine 104 (2019) 291–298. doi.org/10.1016/j.compbiomed.2018.11.005
16. Susumu Tao, Joao AC Lima, Luisa A. Ciuffo, Konstantinos N. Aronis, Timm M. Dickfeld, Michael Stillabower, Robert G. Weiss, Gordon F. Tomaselli, Hiroshi Ashikaga, Katherine C. Wu. Impact of left atrial function on ventricular arrhythmia in primary prevention implantable cardioverter-defibrillator candidates. Submitted.
17. Natalia Trayanova, From genetics to smart watches: developments in precision cardiology. Nature Reviews Cardiology, volume 16, pages72–73 (2019). https://doi.org/10.1038/s41569-018-0149-y.
18. Uthman L, Nederlof R, Eerbeek O, Baartscheer A, Schumacher C, Buchholtz N, Hollmann MW, Coronel R, Weber NC, Zuurbier CJ, Delayed ischemic contracture onset by Empagliflozin associates with NHE-1 inhibition and is dependent on insulin in isolated mouse hearts. Cardiovasc Res. 2019 Jan 12. doi: 10.1093/cvr/cvz004. 
19. Dongdong Deng, Adityo Prakosa, Julie Shade, Plamen Nikolov and Natalia A. Trayanova, Sensitivity of ablation targets prediction to electrophysiological parameter variability in image-based computational models of ventricular tachycardia in post-patients. Frontiers in Physiology, 2019: 10 (628). DOI: 10.3389/fphys.2019.00628
20. Rheeda L. Ali, Joe B. Hakim, Patrick M. Boyle, Sohail Zahid, Bhradeev Sivasambu, Joseph E. Marine, Hugh Calkins, Natalia A. Trayanova, and David D. Spragg.  Arrhythmogenic propensity of the fibrotic substrate after atrial fibrillation ablation: a longitudinal study using magnetic resonance imaging-based atrial models. Cardiovascular Research (2019) 115, 1757–1765.  https://doi.org/10.1093/cvr/cvz083
21. Konstantinos N Aronis, Rheeda L Ali, Jialiu A Liang, Shijie Zhou1 and Natalia A Trayanova. Understanding AF Mechanisms Through Computational Modelling and Simulations. Arrhythmia & Electrophysiology Review 2019;8(3):210–9. DOI: https://doi.org/10.15420/aer.2019.28.2
22. Laura R. Bear, Oumayma Bouhamama, Matthijs Cluitmans, Josselin Duchateau, Richard D. Walton, Emma Abell, Charly Belterman, Michel Haissaguerre, Olivier Bernus, Ruben Coronel, Rémi Dubois. Advantages and pitfalls of non invasive electrocardiographic imaging. Journal of Electrocardiology, 2019. https://doi.org/10.1016/j.jelectrocard.2019.08.007
23. Patrick M. Boyle, Tarek Zghaib, Sohail Zahid, Rheeda L. Ali, Dongdong Deng, William H. Franceschi, Joe B. Hakim, Michael J. Murphy, Adityo Prakosa, Stefan L. Zimmerman, Hiroshi Ashikaga, Joseph E. Marine, Aravindan Kolandaivelu, Saman Nazarian, David D. Spragg, Hugh Calkins and Natalia A. Trayanova. Computationally guided personalized targeted ablation of persistent atrial fibrillation. Nature biomedical engineering, 2019. https://doi.org/10.1038/s41551-019-0437-9
24. Michel Haïssaguerre, Koonlawee Nademanee, Méleze Hocini, MD, Ghassen Cheniti, MD, Josselin Duchateau, Antonio Frontera, Frédéric Sacher, Nicolas Derval, Arnaud Denis, Thomas Pambrun, Rémi Dubois, Pierre Jaïs, David Benoist, Richard D. Walton, Akihiko Nogami, Ruben Coronel, Mark Potse, Olivier Bernus. Depolarization versus repolarization abnormality underlying inferolateral J-wave syndromes: New concepts in sudden cardiac death with apparently normal hearts. Heart Rhythm 2019;16:781–790. https://doi.org/10.1016/j.hrthm.2018.10.040
25. Michel Haissaguerre, Ghassen Cheniti, William Escande, Alexandre Zhao, Méleze Hocini, Olivier Bernus. Idiopathic ventricular fibrillation with repetitive activity inducible within the distal Purkinje system. Heart Rhythm 2019;16:1268–1272. https://doi.org/10.1016/j.hrthm.2019.04.012
26. Steven A. Niederer, Joost Lumens and Natalia A. Trayanova. Computational models in cardiology. Nature reviews – Cardiology, 2019, 16:105. https://doi.org/10.1038/s41569-018-0104-y
27. Philipp Gutruf, Rose T. Yin, K. Benjamin Lee, Jokubas Ausra, Jaclyn A. Brennan, Yun Qiao, Zhaoqian Xie, Roberto Peralta, Olivia Talarico, Alejandro Murillo, Sheena W. Chen, John P. Leshock, Chad R. Haney, Emily A. Waters, Changxing Zhang, Haiwen Luan, Yonggang Huang, Gregory Trachiotis, Igor R. Efimov & John A. Rogers. Wireless, battery-free, fully implantable multimodal and multisite pacemakers for applications in small animal models. Nature Communications, volume 10, 5742 (2019). doi.org/10.1038/s41467-019-13637-w
28. Antoinette F. van Ouwerkerk, Fernanda M. Bosada, Karel van Duijvenboden, Matthew C. Hill, Lindsey E. Montefiori, Koen T. Scholman, Jia Liu, Antoine A. F. de Vries, Bastiaan J. Boukens, Patrick T. Ellinor, Marie José T. H. Goumans, Igor R. Efimov, Marcelo A. Nobrega, Phil Barnett, James F. Martin & Vincent M. Christoffels. Identification of atrial fibrillation associated genes and functional non-coding variants. Nature Communications, volume 10, 4755 (2019). doi.org/10.1038/s41467-019-12721-5
29. Vigneshwaran V, Sands GB, LeGrice IJ, Smaill BH, Smith NP. Reconstruction of coronary circulation networks: A review of methods. Microcirculation. 2019 Jul;26(5):e12542. doi: 10.1111/micc.12542
2018

01. Kedar K. Aras, Ndeye Rokhaya Faye, Brianna Cathey, Igor R. Efimov, Critical volume of human myocardium necessary to maintain ventricular fibrillation. Circ Arrhythm Electrophysiol. 2018;11:e006692. DOI: 10.1161/CIRCEP.118.006692.
02. Aronis KN, Berger RD, Calkins H, Chrispin J, Marine JE, Spragg DD, Tao S, Tandri H, Ashikaga H. Is human atrial fibrillation stochastic or deterministic?-Insights from missing ordinal patterns and causal entropy-complexity plane analysis. Chaos. 2018 Jun; 28(6):063130. doi: 10.1063/1.5023588.
03. Aronis KN, Ashikaga H. Impact of number of co-existing rotors and inter-electrode distance on accuracy of rotor localization. J Electrocardiol. 2018; 51:82-91. doi:10.1016/j.jelectrocard.2017.08.032 
04. Ashikaga H, James RG. Inter-scale information flow as a surrogate for downward causation that maintains spiral waves. Chaos. 2018; 28:075306. doi.org/10.1063/1.5017534.
05. Ashikaga H, Asgari-Targhi A. Locating order-disorder phase transition in a cardiac system. Sci Rep. 2018; 8:1967. DOI:10.1038/s41598-018-20109-6
06. Ashikaga Hiroshi, Francisco Prieto-Castrillo, Mari Kawakatsu and Nina Dehghani. Causal Scale of rotors in a Cardiac System. Frontiers in Physics, April 2018, Vol. 6, article 30. doi: 10.3389/fphy.2018.00030.
07. Jason Bayer, Anton J Prassl, Ali Pashaei, Juan Gomez, Antonio Frontera, Aurel Neic, Gernot Plank, Edward J. Vigmond, “Universal Ventricular Coordinates: A Generic Framework for Describing Position within the Heart and Transferring Data,” Medical Image Analysis, 45 (2018), 83-93. https://doi.org/10.1016/j.media.2018.01.005
08. Laura R Bear, Peter R Huntjens, Richard Walton, Olivier Bernus, Ruben Coronel, Rémi Dubois. Cardiac Electrical Dyssynchrony is Accurately Detected by Noninvasive Electrocardiographic Imaging. Heart Rhythm, Vol 15, No 7, July 2018. https://doi.org/10.1016/j.hrthm.2018.02.024
09. Laura R. Bear, Ian J. LeGrice, Gregory B. Sands, Nigel A. Lever, Denis S. Loiselle,  David J. Paterson,  Leo K. Cheng, and Bruce H. Smaill. How Accurate is Inverse Electrocardiographic Mapping? A Systematic In vivo Evaluation. Circulation Arrhythmia and Electrophysiology. 2018; 11:e006108. doi: 10.1161/CIRCEP.117.006108.
10. Laurens P. Bosman, Arjan Sammani, Cynthia A. James, Julia Cadrin-Tourigny, Hugh Calkins, J. Peter van Tintelen, Richard N.W. Hauer, Folkert W. Asselbergs,  Anneline S.J.M. teRiele. Predicting arrhythmic risk in arrhythmogenic right ventricular cardiomyopathy: A systematic review and meta-analysis. Heart Rhythm (2018), doi:10.1016/j.hrthm.2018.01.031.
11. Patrick M. Boyle, Joe B. Hakim, Sohail Zahid, William H. Franceschi, Michael J. Murphy, Adityo Prakosa, Konstantinos N. Aronis, Tarek Zghaib, Muhammed Balouch, Esra G. Ipek, Jonathan Chrispin, Ronald D. Berger, Hiroshi Ashikaga, Joseph E. Marine, Hugh Calkins, Saman Nazarian, David D. Spragg and Natalia A. Trayanova, The Fibrotic Substrate in Persistent Atrial Fibrillation Patients: Comparison Between Predictions From Computational Modeling and Measurements From Focal Impulse and Rotor Mapping. Frontiers in Physiology, August 2018, Vol. 9, Article 1151. doi: 10.3389/fphys.2018.01151.  
12. PM Boyle, JB Hakim, S Zahid, WH Franceschi, MJ Murphy, EJ Vigmond, R Dubois, M Haïssaguerre,  M Hocini, P Jaïs, NA Trayanova, H Cochet, Comparing Reentrant Drivers Predicted by Image-Based Computational Modeling and Mapped by Electrocardiographic Imaging in Persistent Atrial Fibrillation, Frontiers in Physiology, April 2018, Vol. 9, Article 414. doi: 10.3389/fphys.2018.00414.
13. Ruben Coronel. Activation-repolarization mapping to guide VT-ablation without the need to induce the arrhythmia. International Journal of Cardiology (2018) – 26607- 2. doi.org/10.1016/j.ijcard.2018.06.058.
14. Dongdong Deng, Plamen Nikolov, Hermenegild J. Arevalo, Natalia A. Trayanova. Optimal contrast-enhanced MRI image thresholding for accurate prediction of ventricular tachycardia using ex-vivo high resolution models. Computers in Biology and Medicine, Volume 102, 1 November 2018, Pages 426-432. doi.org/10.1016/j.compbiomed.2018.09.031.
15. Gloschat C, Aras K, Gupta S, Faye NR, Zhang H, Syunyaev RA, Pryamonosov RA, Rogers JM, Kay MW, Efimov IR, RHYTHM: An Open Source Imaging Toolkit for Cardiac Panoramic Optical Mapping. Scientific Reports, 2018 Feb 13; 8(1): 2921. PMID: 29440763. doi: 10.1038/s41598-018-21333-w
16. Michel Haïssaguerre, Koonlawee Nademanee, Mélèze Hocini, Ghassen Cheniti, Josselin Duchateau, Antonio Frontera, Frédéric Sacher, Nicolas Derval, Arnaud Denis, Thomas Pambrun, Rémi Dubois, Pierre Jaïs, David Benoist, Richard D. Walton, Akihiko Nogami, Ruben Coronel, Mark Potse, Olivier Bernus, Depolarization versus repolarization abnormality underlying inferolateral J wave syndromes – new concepts in sudden cardiac death with apparently normal hearts, Heart Rhythm 2018,  doi.org/10.1016/j.hrthm.2018.10.040.
17. Michel Haissaguerre, Mélèze Hocini, Ghassen Cheniti, Josselin Duchateau, Frédéric Sacher, Stéphane Puyo, Hubert Cochet, Masateru Takigawa, Arnaud Denis, Ruairid Martin, Nicolas Derval, Pierre Bordachar, Philipper Ritter, Sylvain Ploux, Thomas Pambrun, Nicolas Klotz, Grégoire Massouillié, Xavier Pillois, Corentin Dallet, Jean-Jacques Schott, Solena Le Scouarnec, Michael J Ackerman, David Tester, Olivier Piot, Jean-Luc Pasquie, Christophe Leclerc, Jean-Sylvain Hermida, Estelle Gandjbakhch, Philippe Maury, Louis Labrousse, Ruben Coronel, Pierre Jais, David Benoist, Edward Vigmond, Mark Potse, Rick Walton, Koonlawee Nademanee, Olivier Bernus and Remi Dubois "Localized structural alterations underlying a subset of unexplained sudden cardiac death", Circ Arrhythm Electrophysiol. 2018; 11:e006120. DOI: 10.1161/CIRCEP.117.006120.
18. Bjarke Jensen, Bastiaan J Boukens, Dane A Crossley II, Justin Conner, Rajiv A Mohan, Karel van Duijvenboden, Alex V Postma, Christopher R Gloschat, Ruth M Elsey, David Sedmera, Igor R Efimov, Vincent M Christoffels, Specialized impulse conduction pathway in the alligator heart, eLife 2018;7:e32120. doi.org/10.7554/eLife.32120
19. Khwaounjoo P, Trew ML, Sands GB, Legrice IJ, Gillis AM, Smaill BH. Cardiac fibrosis and ventricular arrhythmogenesis in hypertensive heart disease progression. Heart Rhythm 2018 (Abstract), Vol. 15, n°5, May supplement 2018. B-PO01-007
20. Hsiao-Chun Amy Lin, Xosé Luís Déan-Ben, Michael Reiss, Verena Schöttle, Christian A. Wahl-Schott, Igor R. Efimov  & Daniel Razansky, Ultrafast Volumetric Optoacoustic Imaging of Whole Isolated Beating Mouse Heart, Scientific reports (2018) 8:14132. DOI:10.1038/s41598-018-32317-1
21. Alexandra D. Loucks, Thomas O’Hara and Natalia A. Trayanova, Degradation of T-Tubular Microdomains and Altered cAMP Compartmentation Lead to Emergence of Arrhythmogenic Triggers in Heart Failure Myocytes: An in silico Study. Frontiers in Physiology, 2018, 9:1737. doi: 10.3389/fphys.2018.01737
22. Marine E. Martinez, Richard D. Walton, Jason D. Bayer, Michel Haïssaguerre, Edward J. Vigmond, Mélèze Hocini and Olivier Bernus, "Role of the Purkinje-muscle junction on the ventricular repolarization heterogeneity in the healthy and ischemic ovine ventricular myocardium", Frontiers in Physiology, June 2018, Vol. 9, Article 718. doi: 10.3389/fphys.2018.00718
23. Steven A. Niederer, Joost Lumens, Natalia A. Trayanova, Computational models in cardiology. Nature Reviews Cardiology (Oct. 2018). doi.org/10.1038/s41569-018-0104-y.
24. Gabriela M. Orgeron, Aditya Bhonsale, Federico Migliore, Cynthia A. James, Crystal Tichnell, Brittney Murray, Emanuele Bertaglia, Julia Cadrin-Tourigny, Pietro De Franceschi, Jane Crosson, Harikrishna Tandri, Domenico Corrado, Hugh Calkins, Subcutaneous Implantable Cardioverter-Defibrillator in Patients With Arrhythmogenic Right Ventricular Cardiomyopathy / Dysplasia: A Transatlantic Experience, J Am Heart Assoc. 2018;7:e008782. DOI: 10.1161/JAHA.118.008782.
25. Gabriela M. Orgeron, Anneline te Riele, Crystal Tichnell, Weijia Wang, Brittney Murray, Aditya Bhonsale, Daniel P. Judge, Ihab R. Kamel,  Stephan L. Zimmerman, Harikrishna Tandri,  Hugh Calkins and Cynthia A. James. Performance of the 2015 International Task Force Consensus Statement Risk Stratification Algorithm for Implantable Cardioverter-Defibrillator Placement in Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy. Circulation: Arrhythmia and Electrophysiology. 2018; 11:e005593. doi.org/10.1161/CIRCEP.117.005593.
26. Pashakhanloo F., Herzka D.A., Halperin H., McVeigh E.R., Trayanova N.A., Role of 3-Dimensional Architecture ofScar and Surviving Tissue in VentricularTachycardia, Circ Arrhythm Electrophysiol. 2018;11:e006131. DOI: 10.1161/CIRCEP.117.006131
27. Adityo Prakosa, Hermenegild J. Arevalo, Dongdong Deng, Patrick M. Boyle, Plamen P. Nikolov, Hiroshi Ashikaga, Joshua J. E. Blauer, Elyar Ghafoori, Carolyn J. Park, Robert C. Blake III, Frederick T. Han, Rob S. MacLeod, Henry R. Halperin, David J. Callans, Ravi Ranjan, Jonathan Chrispin, Saman Nazarian and Natalia A. Trayanova. Personalized virtual-heart technology for guiding the ablation of infarct-related ventricular tachycardia, Nature Biomedical Engineering, 2018, volume 2, 732–740. Doi 10.1038/s41551-018-0282-2
28. Qiao Y, Dong Q, Li B, Obaid S, Miccile C, Yin R, Talapatra T, Lin Z, Li S, Li Z, Efimov IR, Multiparametric slice culture platform for the investigation of human cardiac tissue physiology. Prog Biophys Mol Biol. 2018 Jun 27. pii: S0079-6107(18)30012-9. doi: 10.1016/j.pbiomolbio.2018.06.001.
29. Kenta Tsutsui, Oliver J. Monfredi, Syevda G. Sirenko-Tagirova, Larissa A. Maltseva, Rostislav Bychkov, Mary S. Kim, Bruce D. Ziman, Kirill V. Tarasov, Yelena S. Tarasova, Jing Zhang, Mingyi Wang, Alexander V. Maltsev, Jaclyn A. Brennan, Igor R. Efimov, Michael D. Stern, Victor A. Maltsev, Edward G. Lakatta, A coupled-clock system drives the automaticity of human sinoatrial nodal pacemaker cells, Sci. Signal. 11, eaap7608 (2018). DOI: 10.1126/scisignal.aap7608.
30. Uthman L, Baartscheer A, Schumacher CA, Fiolet JWT, Kuschma MC, Hollmann MW, Coronel R, Weber NC, Zuurbier CJ. Direct Cardiac Actions of Sodium Glucose Cotransporter 2 Inhibitors Target Pathogenic Mechanisms Underlying Heart Failure in Diabetic Patients. Front Physiol. 2018 Nov 21;9:1575. doi: 10.3389/fphys.2018.01575
31. Veldkamp MW, Geuzebroek GSC, Baartscheer A, Verkerk AO, Schumacher CA, Suarez GG, Berger WR, Casini S, van Amersfoorth SCM, Scholman KT, Driessen AHG, Belterman CNW, van Ginneken ACG, de Groot JR, de Bakker JMT, Remme CA, Boukens BJ, Coronel R. Neurokinin-3 receptor activation selectively prolongs atrial refractoriness by inhibition of a background K+ channel. Nat Commun. 2018 Oct 19;9(1):4357. doi: 10.1038/s41467-018-06530-5.
32. Weijia Wang, Gabriela Orgeron, Crystal Tichnell, Brittney Murray, Jane Crosson, Oliver Monfredi, Julia Cadrin-Tourigny, Harikrishna Tandri, Hugh Calkins, Cynthia A. James, ScM, Impact of Exercise Restriction on Arrhythmic Risk Among Patients With Arrhythmogenic Right Ventricular Cardiomyopathy. J Am Heart Assoc. 2018;7:e008843. DOI: 10.1161/JAHA.118.008843
33. Weijia Wang, Julia Cadrin-Tourigny, Aditya Bhonsale, Crystal Tichnell, Brittney Murray, Oliver Monfredi, Jonathan Chrispin, Jane Crosson, Harikrishna Tandri, Cynthia A. James, Hugh Calkins, Arrhythmic outcome of arrhythmogenic right ventricular cardiomyopathy patients without implantable defibrillators. J Cardiovasc Electrophysiol. 2018;1–7. DOI: 10.1111/jce.13668.
34. Melanie A. Zile, and Natalia A. Trayanova, Increased thin filament activation enhances alternans in human chronic atrialfibrillation. Am J Physiol Heart Circ Physiol 315: H1453–H1462, 2018. doi:10.1152/ajpheart.00658.2017.
2017

01. Aronis KN, BergerRD, and Ashikaga H. Rotors: How do we know when they are real? Circ Arrhythm Electrophysiol. 2017; 10:e005634. doi:10.1161/CIRCEP.117.005634
02. Coronel R. Restitution slope is determined by the steady state action potential duration: law and disorder. Cardiovasc Res. 2017 Jun 1; 113(7):705-707. doi: 10.1093/cvr/cvx080.
03. Coronel R. The pro- or antiarrhythmic actions of polyunsaturated fatty acids and of cholesterol. Pharmacol Ther. 2017 Aug; 176:40-47. doi: 10.1016/j.pharmthera.2017.02.004. Epub 2017 Feb 3.
04. Kang C; Badiceanu A, Brennan JA, Gloschat C, Qiao Y, Trayanova N, Efimov IR, β-Adrenergic stimulation augments transmural dispersion of repolarization via modulation of delayed rectifier currents IKs and IKr in the human ventricle. Scientific Reports, 2017 Nov 21; 7(1): 15922. PMID: 29162896. DOI:10.1038/s41598-017-16218-3
05. Sanjay R Kharche, Edward Vigmond, Igor Efimov, Halina Dobrzynski, "Computational assessment of the functional role of sinoatrial node exit pathways in the human heart," PloS ONE, 2(9): e0183727, 2017. doi 10.1371/journal.pone.0183727
06. Meijborg VMF, Belterman CNW, de Bakker JMT, Coronel R, Conrath CE. Mechano-electric coupling, heterogeneity in repolarization and the electrocardiographic T-wave. Prog Biophys Mol Biol. 2017 Nov; 130(Pt B):356-364. doi: 10.1016/j.pbiomolbio.2017.05.003. Epub 2017 May 17. 
07. Sanjay R Kharche, Edward Vigmond, Igor Efimov, Halina Dobrzynski, "Computational assessment of the functional role of sinoatrial node exit pathways in the human heart," PloS ONE, 2(9): e0183727, 2017. https://doi.org/10.1371/journal.pone.0183727
08. Smit NW, Cócera Ortega L, Végh AMD, Meijborg VMF, Smits AM, Klerk M, Tijsen AJM, Tan HL, Goumans MHT, Boink GJJ, Coronel R. Human Cardiomyocyte Progenitor Cells in Co-culture with Rat Cardiomyocytes Form a Pro-arrhythmic Substrate: Evidence for Two Different Arrhythmogenic Mechanisms. Front Physiol. 2017 Oct 12; 8:797. doi: 10.3389/fphys.2017.00797. eCollection 2017.
09. Veerman CC, Podliesna S, Tadros R, Lodder EM, Mengarelli I, de Jonge B, Beekman L, Barc J1, Wilders R, Wilde AAM, Boukens BJ, Coronel R, Verkerk AO, Remme CA, Bezzina CR. The Brugada Syndrome Susceptibility Gene HEY2 Modulates Cardiac Transmural Ion Channel Patterning and Electrical Heterogeneity. Circ Res. 2017 Aug 18; 121(5):537-548. doi: 10.1161 / CIRCRESAHA.117.310959. Epub 2017 Jun 21.
10. Vigmond EJ, Efimov IR, Rentschler SL, Coronel R, Boukens BJ. Fractionated electrograms with ST-segment elevation recorded from the human right ventricular outflow tract. Heart Rhythm Case Rep. 2017 Sep 28; 3(11):546-550. PMID: 29204352. doi: 10.1016/j.hrcr.2017.08.010